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Nitrogenous bases covalently linked to a sugar with and without phosphate groups; used for synthesis, cell signaling, and as cofactors in enzymatic reactions; includes pyrimidine, purine, pyridine, flavin, pyrrolopyrimidine, and triazole varieties.
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Oxidized low density lipoprotein (mouse) (Mouse ox-LDL) is an oxidized low density lipoprotein (LDL). It induces atherosclerosis (AS) by facilitating endothelial dysfunction and accelerating the VSMCs growth and migration, making it suitable for constructing an in vitro model of AS.
Induces atherosclerosis (AS)
Facilitates endothelial dysfunction
Accelerates VSMCs growth and migration
Can be used to construct an in vitro model of AS
Upregulates mRNA and protein expressions of long noncoding RNA TUG1 and receptor tyrosine kinase-like orphan receptor 2 (ROR2)
Promotes the proliferation of HA-VSMCs
Enhances migration and invasion abilities
Increases the expressions of metastasis-related proteins β-catenin and Vimentin in human aortic vascular smooth muscle cells
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A thymidine nucleoside derivative commonly used to identify proliferating cells; intraperitoneal injection of BrdU can be used in combination with neuronal markers to detect adult neurogenesis in animal models; commonly used as a marker of proliferation of cancer cells in vitro
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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MW 392.15 Da, Purity >95%. Potent, specific adenosine kinase inhibitor (IC₅₀ = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).